Bacterial adhesion inhibition on water treatment membrane by a modified HHC-36 antimicrobial peptide

نویسندگان

چکیده

Antimicrobial peptides (AMPs) are now used instead of conventional antimicrobial substances because they do not induce resistance in microbial cells. The first goal this study was to investigate how various dissolution solvents, such as dimethyl sulfoxide (DMSO), phosphate buffered saline (PBS) and autoclaved deionized (DI) water, affect the potency an AMP (HHC-36) modified with L -propargylglycine (PraAMP) against Pseudomonas aeruginosa PAO1, Escherichia coli, Bacillus sp. potential application HHC-36 a biofouling control agent on water treatment membranes then investigated using membrane fouling bacterium model. At concentrations greater than 0.5 mg/mL, demonstrated significant antibacterial efficacy all bacteria species. However, initial DMSO had impact its effects. alone (≥ 12.4% vol/vol) exhibited bacterial growth inhibition. This finding is noteworthy commonly solvent for agents that insoluble water. Overall, by disrupting cell membranes, able inactivate cells membrane. recapitulates feasible use environmentally friendly antibiofouling processes.

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ژورنال

عنوان ژورنال: Environmental Engineering Research

سال: 2022

ISSN: ['1226-1025', '2005-968X']

DOI: https://doi.org/10.4491/eer.2022.155